谷戰軍課題組

我們課題組主要研究方向為納米材料的可控合成及其生物效應研究。多年來一直從事新型多功能納米材料的設計合成及其在生物成像,癌癥治療和納米生物安全性的研究工作。以多功能納米材料的設計合成為核心,以材料的功能化為導向,以癌癥綜合治療為目的,開發出過渡金屬離子摻雜、多重核殼納米結構調控、質子插層等納米材料制備新方法,構建了一系列具有特定功能的熒光上轉換、過渡金屬硫化物/硒化物、多酸納米團簇等新型納米粒子;針對生物納米材料的客觀需求,利用同步輻射、生物成像等手段系統研究了這些納米粒子的生物分布、轉化、代謝和清除過程,獲取理化特性對其體內過程及生物安全性的影響規律;進一步地,利用納米粒子獨特的理化性質和多藥物共輸運能力,探索了納米材料介導的熱療/化療/放療/光動力治療等多模態協同治療策略,揭示了納米材料介導的不同治療手段的協同增效機制,為優化納米材料介導的腫瘤綜合治療提供了依據,同時也為臨床優化腫瘤綜合治療策略提供了借鑒。


我的學術主頁:

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Research Projects

1. Synthesis of one-dimensional nanostructures by developing new synthetic approaches. Development of upconversion nanoparticle derived multifunctional materials for bioimaging, sensor and drug delivery.


2.   Mutilfunctional nanomaterials for in vitro and in vivo bio-imaging.

3.   Smart responsive nanocarriers and nanodrug.

4.   Mutilfunctional nanomaterials for combination therapy.




基于我們課題組研究工作的一些綜述文章

主題#1:X射線響應的納米材料用于腫瘤放療增敏或放療防護

  • Emerging Strategies of Nanomaterial-Mediated Tumor Radiosensitization. Advanced Materials 2019,31, 1802244.

  • Harnessing Tumor Microenvironment for Nanoparticle-Mediated Radiotherapy. Advanced Therapeutics 2018, 1, 1800050.

  • Strategies based on metal-based nanoparticles for hypoxic-tumor radiotherapy. Chemical Science 2019, 10, 6932-6943.

  • 多功能納米材料在腫瘤放療增敏中的應用. 物理化學學報 2018, 34, 140-167.

主題#2:近紅外光響應的納米生物材料的設計與診療應用

  • Graphene-Based Smart Platforms for Combined Cancer Therapy. Advanced Materials 2019, 31, 1800662.

  • Recent Advances in Upconversion Nanoparticles-Based Multifunctional Nanocomposites for Combined Cancer Therapy. Advanced Materials 2015, 27, 7692.

  • Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications. Advanced Materials 2013, 25, 3758-3779.

  • Two-dimensional transition metal dichalcogenide nanomaterials for combination cancer therapy. Journal of Materials Chemistry B 2017, 5, 1873-1895.

  • Recent advances of stimuli-responsive systems based on transition metal dichalcogenides for smart cancer therapy. Journal of Materials Chemistry B 2019, 7, 2588-2607.

  • Design, Synthesis, and Surface Modification of Materials Based on Transition-Metal Dichalcogenides for Biomedical Applications. Small Methods 2017, 1, 1700220.

  • Transition Metal Dichalcogenides for Biomedical Applications. In Two Dimensional Transition Metal Dichalcogenides: Synthesis, Properties, and Applications; Arul, N. S., Nithya, V. D., Eds.; Springer Singapore: Singapore, 2019; pp 241-292. (書籍章節)

主題#3:NO或CO等氣體控釋體系的構筑與腫瘤治療或傷口抗菌應用

  • Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials. Small 2019, 15, 1904382.

  • Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives. Theranostics 2020, 10, 757-781.

主題#4:納米生物效應+納米毒理學+納米生物醫學

  • Precise nanomedicine for intelligent therapy of cancer. Science China Chemistry 2018, 61, 1503-1552.

  • A Safe-by-Design Strategy towards Safer Nanomaterials in Nanomedicines. Advanced Materials 2019, 31, 1805391.

  • Safety Assessment of Nanomaterials to Eyes: An Important but Neglected Issue. Advanced Science 2019, 6, 1802289.

  • Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species. Chemistry – An Asian Journal 2013, 8, 2342-2353.

  • Nanotoxicity of Near Infrared Nanomaterials. In Near-infrared Nanomaterials: Preparation, Bioimaging and Therapy Applications; The Royal Society of Chemistry, 2016; pp 355-402. (書籍章節)









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